Neuroglobin: Endogenous Neuroprotectant or Maintenance of Homeostasis?
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چکیده
منابع مشابه
Neuroglobin: endogenous neuroprotectant or maintenance of homeostasis?
Neuroglobin: Endogenous Neuroprotectant or Maintenance of Homeostasis? To the Editor: We would like to comment on the latest experimental stroke study in a neuroglobin (Ngb) knock-in mouse by Wang et al1 The intriguing idea that Ngb could act as a reservoir of oxygen, facilitate oxygen transportation or act as a scavenger of reactive oxygen species in the brain has been the main research hypoth...
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متن کاملInducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.
Nitric oxide (NO) derived from the inducible isoform of NO synthase (iNOS) is an inflammatory product implicated both in secondary damage and in recovery from brain injury. To address the role of iNOS in experimental traumatic brain injury (TBI), we used 2 paradigms in 2 species. In a model of controlled cortical impact (CCI) with secondary hypoxemia, rats were treated with vehicle or with 1 of...
متن کاملThe major cholesterol metabolite cholestane-3β,5α,6β-triol functions as an endogenous neuroprotectant.
Overstimulation of NMDA-type glutamate receptors is believed to be responsible for neuronal death of the CNS in various disorders, including cerebral and spinal cord ischemia. However, the intrinsic and physiological mechanisms of modulation of these receptors are essentially unknown. Here we report that cholestane-3β,5α,6β-triol (triol), a major metabolite of cholesterol, is an endogenous neur...
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ژورنال
عنوان ژورنال: Stroke
سال: 2008
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.108.526533